Previous Clinical Trials

Reading Hospital participates in Clinical Trials in the following therapeutic areas:

  • Cardiovascular
  • Endocrinology
  • Gastrointestinal
  • Infectious Disease
  • Interventional Radiology
  • Orthopedics
  • Pulmonary
  • Trauma
  • Vascular
  • Wound Care

The studies that are enrolling now are listed under Current Clinical Trials, but highlights of our past research experience are listed below.


HF Biomarkers

"A Blood Collection from Patients Presenting with Suspected New Onset or Exacerbated Heart Failure"

Investigator: Jared Green, DO

The purpose of this study is to validate a blood test used to diagnose and assess the severity of heart failure.

Study is closed to enrollment.

Heart Attack


Affordability and Real-world Antiplatelet Treatment Effectiveness after Myocardial Infarction Study

Investigator: Eric Elgin, MD

The purpose of this study is to learn about the impact of medication copayments on how patients take antiplatelet medication after having a heart attack and how this influences health and the use of healthcare.  Study is closed to enrollment.

New Onset of Atrial Fibrillation


Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II

Investigator: David Scollan, MD, PhD

This study is for patients who have new diagnosis of atrial fibrillation within 6 months or who have been started on new anticoagulants within 3 months.  The purpose is to better understand how patients with atrial fibrillation are cared for by their health provider and what happens to them because of the care they receive.  Study is closed to enrollment.

Emergency Medicine

Pulmonary Embolism


MultiEnter Trial of Rivaroxaban for Early DisCharge of PUlmonaRY Embolism from the Emergency DepartmentInvestigator: John Derderian, DO

Investigator: John Derderian, DO

The purpose of this study is to evaluate the safety of discharging low-risk Pulmonary Embolism (a condition in which one or more arteries in the lungs become blocked by a blood clot) subjects from the Emergency Department on the medication rivaroxaban.

Learn more about the MERCURY PE trial or call the Clinical Trials Office at 484-628-8585.


Infectious Disease


Efficacy, Immunogenicity, and Safety Study of Clostridium difficile Toxoid Vaccine in Subjects at Risk for C. difficile Infection

Investigator: Debra Powell, MD

This study is recruiting patients who are age 50 or older and planning an upcoming hospitalization of more than 72 hours for a surgical procedure OR who have had at least two hospital stays and have received antibiotics in the past year.

Learn more about the Cdiffense trial or call the Clinical Trials Office at 484-628-8585.



A Phase 4, Observational, Multicenter, 10-year Prospective Cohort Safety Study Comparing Subjects with HIV-associated Abdominal Lipohypertrophy Exposed to EGRIFTA® (tesamorelin for injection) to a Similar Group of Subjects Not Exposed to EGRIFTA®

Investigator: Kathleen McElwee, MD

This study is a long-term observational study comparing subjects with HIV-associated belly fat who take the medicine, EGRIFTA with subjects of a similar group that haven's taken Egrifta.

Learn more about the Egrifta trial or call the Clinical Trials Office at 484-628-8585.

Diabetic Retinopathy

A Prospective, Randomized, Placebo-Controlled, Double-Blind Clinical Trial to Evaluate Whether EGRIFTA® (Tesamorelin for injection), 2 mg Once Daily SC, Increases the Risk of Development or Progression of Diabetic Retinopathy When Administered to HIV-infected Subjects with Abdominal Lipohypertrophy and Concomitant Diabetes

Investigator: Robert Jones, MD

Recruiting patients for a trial to evaluate whether the drug EGRIFTA, given by injection increases the risk of developing diabetic retinopathy in a person with positive HIV, abdominal belly fat and diabetes. Study is closed to enrollment. 

Lyme Disease

A Study for the Collection of Prospective Specimens for Investigational Studies of the BioPlex 2200 Lyme Total Kit

Investigator: Debra Powell, MD

Recruiting subjects who are 18 years or older with clinically diagnosed Lyme Disease who have early, convalescent, or late stage complications (neurologic, cardiac, or rheumatologic) of the disease. Study is closed to enrollment. 

Interventional Radiology

Blood Clot


Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis

Investigator: David Sacks, MD

The purpose of this study is to determine which of two treatment strategies used to treat blood clot in the leg will decrease long-term complications; standard anticoagulation versus standard anticoagulation plus the use of medication inserted into the clot to dissolve it. Study is closed to enrollment.


Alzheimer's Disease


Venlafaxine for Depression in Alzheimer's Disease

Investigator: Kolin Good, MD

The purpose of this study is to test the use of the medication venlafaxine to treat depression in Alzheimer's Disease.  Study is closed to enrollment.  



Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research

Investigator: Karen Hoerst, MD  Study is closed to enrollment.  


Acute Stroke Or Transient Ischaemic Attack TrReated with Aspirin or Ticagrelor and Patient Outcomes

Investigator: Karen Hoerst, MD

Recruiting patients who experienced symptoms of Acute Ischaemic Stroke or Transient Ischaemic Attack within last 24 hours.  It will compare aspirin to the medication Ticagrelor taken daily for 90 days after an ischemic stroke in the prevention of stroke, heart attack and death.  Study is closed to enrollment.  


Hip Fracture


A Randomized Controlled Trial of Regional Versus General Anesthesia for Promoting Independence After Hip Fracture

Investigator: Karen Troxell, MD

The purpose of this study is to determine whether spinal anesthesia, when used as a primary anesthetic technique for hip fracture surgery is associated with improved functional recovery and decreased risk of adverse postoperative outcomes compared to general anesthesia.  Study is closed to enrollment.

Women's Health



Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Investigator: Stephen Fehnel, MD

This study is to determine the benefit and safety of relugolix 40 mg once daily, co-administered with low-dose estradiol and norethindrone acetate compared with placebo, on dysmenorrhea and on nonmenstrual pelvic pain.  Study is closed to enrollment.

Overactive Bladder

A Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multi-Center Study to Evaluate the Efficacy, Safety and Tolerability of Combinations of Solifenacin Succinate and Mirabegron Compared to Solifenacin Succinate and Mirabegron Monotherapy in the Treatment of Overactive Bladder 

Investigator: Stephen Fehnel, MD

Recruited patients to see how well two medicines in combination worked compared to taking each medicine alone to treat bladder problems. Study is closed to enrollment. 

Pap Screen for Gential Warts

Clinical Evaluation of the HPV Assay on the BD Viper LT System with Cervical Specimens

Investigator: Stephen Fehnel, MD

Recruited patients with certain types of human papillomavirus (HPV). This study collected cervical specimens that were tested for HPV using the experimental test. This test results will be compared to the current standards of testing for HPV and diagnosing cervical disease. Study is closed to enrollment. 

Uterine Fibroids

Elagolix & Heavy Menstrual Bleeding

A Phase 3 Study to Evaluate the Efficacy and Safety of Elagolix in Combination with Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding associated with Uterine Fibroids in Premenopausal Women

Investigator: Stephen Fehnel, MD

This study seeks to evaluate the efficacy, safety and tolerability of the drug elagolix alone and in combination with estradiol/norethindrone acetate or placebo for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.  Study is closed to enrollment. 

Uterine Fibroids

A Randomized, Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy and Safety of Ulipristal Acetate for the intermittent Treatment of Abnormal Uterine Bleeding Associated with Leiomyomas

Investigator: Stephen Fehnel, MD

Recruited patients with abnormal uterine bleeding who took the medicine or a placebo to see if it would achieve the absence of bleeding. Study is closed to enrollment.