Previous Clinical Trials

Reading Hospital participates in Clinical Trials in the following therapeutic areas:

  • Cardiovascular
  • Endocrinology
  • Gastrointestinal
  • Infectious Disease
  • Interventional Radiology
  • Orthopedics
  • Pulmonary
  • Trauma
  • Vascular
  • Wound Care

The studies that are enrolling now are listed under Current Clinical Trials, but highlights of our past research experience are listed below.

Cardiology

HF Biomarkers

"A Blood Collection from Patients Presenting with Suspected New Onset or Exacerbated Heart Failure"

Investigator: Jared Green, DO

The purpose of this study is to validate a blood test used to diagnose and assess the severity of heart failure.

Heart Attack

ARTEMIS

Affordability and Real-world Antiplatelet Treatment Effectiveness after Myocardial Infarction Study

Investigator: Eric Elgin, MD

The purpose of this study is to learn about the impact of medication copayments on how patients take antiplatelet medication after having a heart attack and how this influences health and the use of healthcare.

MiCORE Study

Myocardial Infarction COmbined device, Recovery Enhancement Study (JHIRB00099938)

Johns Hopkins Primary Investigator: Seth Martin, MD

Investigator: Eric Elgin, MD

The purpose of this study is to assess readmissions in patients who use a mobile application to assist recovery from acute myocardial infarction.

New Onset of Atrial Fibrillation

ORBIT II 

Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II

Investigator: David Scollan, MD, PhD

This study is for patients who have new diagnosis of atrial fibrillation within 6 months or who have been started on new anticoagulants within 3 months.  The purpose is to better understand how patients with atrial fibrillation are cared for by their health provider and what happens to them because of the care they receive.

Heart Failure

CardioMEMS

CardioMEMS Heart Failure System Post Approval Study

Investigator: Jared Green, DO

The purpose of this post-approval study is to educate the use of the CardioMEMS Heart Failure System in qualifying subjects to confirm its safety and effectiveness.

Emergency Medicine

Pulmonary Embolism

MERCURY PE

MultiEnter Trial of Rivaroxaban for Early DisCharge of PUlmonaRY Embolism from the Emergency DepartmentInvestigator: John Derderian, DO

Investigator: John Derderian, DO

The purpose of this study is to evaluate the safety of discharging low-risk Pulmonary Embolism (a condition in which one or more arteries in the lungs become blocked by a blood clot) subjects from the Emergency Department on the medication rivaroxaban.

Anticoagulants and Bleeding

SOAR

Safety of Oral Anticoagulants Registry: A National, Hospital-based Sentinel Surveillance Study of the Clinical and Economic Impact of Bleeding and Bleeding Concerns due to the use of Oral Anticoagulants

Investigator: Adam Sigal, MD

This is a registry study to identify the clinical and economic impact of safety concerns around the use of oral anticoagulants, the evaluation and management in an emergency department or on inpatient units. The data is used to improve approaches to the management and development of a new protocol safety standard.

 

Endocrinology and Diabetes

Prediabetes

Sweetch

Effectiveness of a Smartphone-Assisted Coaching System to Improve Glucose Homeostasis in Adults with Prediabetes

Investigator: Brian Kane, MD

The purpose of this study is to test the usefulness of Sweetch, a personalized mobile-health platform coaching system (mobile phone app) designed to promote adherence to physical activity guidelines for people with prediabetes.

Infectious Disease

Cdiffense

Efficacy, Immunogenicity, and Safety Study of Clostridium difficile Toxoid Vaccine in Subjects at Risk for C. difficile Infection

Investigator: Debra Powell, MD

This study is recruiting patients who are age 50 or older and planning an upcoming hospitalization of more than 72 hours for a surgical procedure OR who have had at least two hospital stays and have received antibiotics in the past year.

HIV

Egrifta

A Phase 4, Observational, Multicenter, 10-year Prospective Cohort Safety Study Comparing Subjects with HIV-associated Abdominal Lipohypertrophy Exposed to EGRIFTA® (tesamorelin for injection) to a Similar Group of Subjects Not Exposed to EGRIFTA®

Investigator: Kathleen McElwee, MD

This study is a long-term observational study comparing subjects with HIV-associated belly fat who take the medicine, EGRIFTA with subjects of a similar group that haven's taken Egrifta.

Diabetic Retinopathy

A Prospective, Randomized, Placebo-Controlled, Double-Blind Clinical Trial to Evaluate Whether EGRIFTA® (Tesamorelin for injection), 2 mg Once Daily SC, Increases the Risk of Development or Progression of Diabetic Retinopathy When Administered to HIV-infected Subjects with Abdominal Lipohypertrophy and Concomitant Diabetes

Investigator: Robert Jones, MD

Recruiting patients for a trial to evaluate whether the drug EGRIFTA, given by injection increases the risk of developing diabetic retinopathy in a person with positive HIV, abdominal belly fat and diabetes.

Lyme Disease

A Study for the Collection of Prospective Specimens for Investigational Studies of the BioPlex 2200 Lyme Total Kit

Investigator: Debra Powell, MD

Recruiting subjects who are 18 years or older with clinically diagnosed Lyme Disease who have early, convalescent, or late stage complications (neurologic, cardiac, or rheumatologic) of the disease.

Clostridium difficile

ECOSPOR

A RandomizEd, Double Blind, Placebo COntrolled, Parallel Group Study of SER 109 to Prevent Recurrent ClOstRidium Difficile Infection

Investigator: Debra Powell, MD

This study is recruiting patients who have had at least 3 episodes of C. difficile in the last year, and who have responded to antibiotic treatment.

Influenza A

FLU-IGIV

Exploring Safety & Clinical Benefit of Anti-Influenza Immune Globulin Intravenous in Hospitalized Adults With Influenza A

Investigator: Debra Powell, MD

This study aims to evaluate a treatment for people who are hospitalized with the flu.

Interventional Radiology

Blood Clot

ATTRACT

Acute Venous Thrombosis: Thrombus Removal with Adjunctive Catheter-Directed Thrombolysis

Investigator: David Sacks, MD

The purpose of this study is to determine which of two treatment strategies used to treat blood clot in the leg will decrease long-term complications; standard anticoagulation versus standard anticoagulation plus the use of medication inserted into the clot to dissolve it.

Neurology

Alzheimer's Disease

DIADS

Venlafaxine for Depression in Alzheimer's Disease

Investigator: Kolin Good, MD

The purpose of this study is to test the use of the medication venlafaxine to treat depression in Alzheimer's Disease.

Stroke

PROSPER

Patient-centered Research into Outcomes Stroke patients Prefer and Effectiveness Research

Investigator: Karen Hoerst, MD

SOCRATES

Acute Stroke Or Transient Ischaemic Attack TrReated with Aspirin or Ticagrelor and Patient Outcomes

Investigator: Karen Hoerst, MD

Recruiting patients who experienced symptoms of Acute Ischaemic Stroke or Transient Ischaemic Attack within last 24 hours.  It will compare aspirin to the medication Ticagrelor taken daily for 90 days after an ischemic stroke in the prevention of stroke, heart attack and death.

Orthopedics

Hip Fracture

REGAIN

A Randomized Controlled Trial of Regional Versus General Anesthesia for Promoting Independence After Hip Fracture

Investigator: Karen Troxell, MD

The purpose of this study is to determine whether spinal anesthesia, when used as a primary anesthetic technique for hip fracture surgery is associated with improved functional recovery and decreased risk of adverse postoperative outcomes compared to general anesthesia.

Women's Health

Endometriosis

SPIRIT 1

Efficacy and Safety Study of Relugolix in Women With Endometriosis-Associated Pain

Investigator: Stephen Fehnel, MD

This study is to determine the benefit and safety of relugolix 40 mg once daily, co-administered with low-dose estradiol and norethindrone acetate compared with placebo, on dysmenorrhea and on nonmenstrual pelvic pain.

Overactive Bladder

A Randomized, Double-Blind, Parallel-Group, Placebo- and Active-Controlled, Multi-Center Study to Evaluate the Efficacy, Safety and Tolerability of Combinations of Solifenacin Succinate and Mirabegron Compared to Solifenacin Succinate and Mirabegron Monotherapy in the Treatment of Overactive Bladder 

Investigator: Stephen Fehnel, MD

Recruited patients to see how well two medicines in combination worked compared to taking each medicine alone to treat bladder problems.

HPV

Pap Screens & HPV

Longitudinal Clinical Evaluation of the HPV Assay on the BD Viper LT System with Cervical Specimens

Investigator: Stephen Fehnel, MD

This study collects cervical specimens to test for HPV using an experimental test. These test results will then be compared to the current standards of testing for HPV and diagnosing cervical disease.

Pap Screen for Genital Warts

Clinical Evaluation of the HPV Assay on the BD Viper LT System with Cervical Specimens

Investigator: Stephen Fehnel, MD

Recruited patients with certain types of human papillomavirus (HPV). This study collected cervical specimens that were tested for HPV using the experimental test. This test results will be compared to the current standards of testing for HPV and diagnosing cervical disease.

Obesity

STEP 1

"Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity"

Investigator: Stephen Fehnel, MD

This study will look at the change in participants' body weight from the start to the end of the study. The weight loss in participants taking semaglutide (a new medicine) will be compared to the weight loss of participants taking "dummy" medicine. In addition to taking the medicine, participants will have talks with study staff about healthy food choices, how to be more physically active and what you can do to lose weight.

Uterine Fibroids

Elagolix & Heavy Menstrual Bleeding

A Phase 3 Study to Evaluate the Efficacy and Safety of Elagolix in Combination with Estradiol/Norethindrone Acetate for the Management of Heavy Menstrual Bleeding associated with Uterine Fibroids in Premenopausal Women

Investigator: Stephen Fehnel, MD

This study seeks to evaluate the efficacy, safety and tolerability of the drug elagolix alone and in combination with estradiol/norethindrone acetate or placebo for the management of heavy menstrual bleeding associated with uterine fibroids in premenopausal women.

Uterine Fibroids

A Randomized, Placebo-Controlled, Parallel Group, Multicenter Study to Evaluate the Efficacy and Safety of Ulipristal Acetate for the intermittent Treatment of Abnormal Uterine Bleeding Associated with Leiomyomas

Investigator: Stephen Fehnel, MD

Recruited patients with abnormal uterine bleeding who took the medicine or a placebo to see if it would achieve the absence of bleeding. 

LIBERTY 2

An International Phase 3 Randomized, Double-Blind, Placebo-Controlled Efficacy and Safety Study to Evaluate Relugolix Co-Administered with and without Low-Dose Estradiol and Norethindrone Acetate in Women with Heavy Menstrual Bleeding Associated with Uterine Fibroids

Investigator: Stephen Fehnel, MD

The purpose of this study is to determine the benefit of relugolix 40 mg once daily co-administered with low-dose estradiol and norethindrone acetate compared with placebo for 24 weeks on heavy menstrual bleeding associated with uterine fibroids.

TRAIN

"A Study Evaluate the Safety and Efficacy of Elagolix for the Management of Heavy Menstrual Bleeding Associated with Uterine Fibroids in Premenopausal Women"

Investigator: Stephen Fehnel, MD

The main objective of this study is to asses safety and efficacy of elagolix compared to placebo in reducing heavy menstrual bleeding (HMB) associated with premenopausal women.