Current Clinical Trials

Every treatment, medication, and procedure available today was once tested as part of a clinical trial. These carefully designed scientific studies are among the last steps in the research process, helping doctors continually improve care. The primary goal of clinical trials is to advance medicine by finding better ways to treat and prevent disease. Clinical trials are available through the Clinical Trials Office and McGlinn Cancer Institute.

We have several open clinical trials that can be reviewed below.

For cancer clinical trials, please visit the Cancer Clinical Trials page.

Cardiology

Heart Attack

Call the Clinical Trials Office at 484-628-8585 for information about any available studies.

Heart Failure

GUIDE-HF

"Hemodynamic-GUIDEd Management of Heart Failure"

Investigator: Jared Green, DO

The purpose of this study is to demonstrate the effectiveness of the CardioMEMS™ Heart Failure System in an expanded patient population, including patients with New York Heart Association (NYHA) Class II, III, or IV heart failure with or without a prior hospitalization.

Learn more about the GUIDE-HF trial or call the Clinical Trials Office at 484-628-8585.

REHAB-HF

"A Trial of Rehabilitation Therapy in Older Acute Heart Failure Patients"

Investigator: Jared Green, DO

The purpose of this study is to measure the effect of an exercising training program has on physical function, hospital readmission rates and medical costs for people admitted to the hospital with a diagnosis of heart failure.

Learn more about the REHAB-HF trial or call the Clinical Trials Office at 484-628-8585.

Colonoscopy

Colon Cancer Screening

Biofilm Epidemiology and Mechanisms of Colon Cancer

Investigators: Louis LaLuna, MD; John Altomare, MD; Ravi Ghanta, MD; Christopher Ibrahim, MD; Nirav Shah, MD

This research is being done to learn more about why people get colon cancer. We are looking to identify specific bacteria in the colon that may be linked to the development of colon cancer, and small biopsies will be taken along with other samples to look for these bacteria.

Learn more about the colonoscopy trial or call the Clinical Trials Office at 484-628-8585.

Emergency Medicine

Call the Clinical Trials Office at 484-628-8585 to learn about any new trials.

Endocrinology and Diabetes

Call the Clinical Trials Office at 484-628-8585 for information on new studies.

Infectious Disease

Candidemia

ReSTORE

Study of Rezafungin Compared to Caspofungin in Subjects With Candidemia and/or Invasive Candidiasis

Investigator: Debra Powell, MD

The purpose of this pivotal study is to determine if intravenous Rezafungin is efficacious and safe in the treatment of candidemia and/or invasive candidiasis when compared to caspofungin (followed by optional oral fluconazole).

Learn more about the ReSTORE trial here or call the Clinical Trials Office at 484-628-8585.

Influenza A

FLU-IGIV

Exploring Safety & Clinical Benefit of Anti-Influenza Immune Globulin Intravenous in Hospitalized Adults With Influenza A

Investigator: Debra Powell, MD

This study aims to evaluate a treatment for people who are hospitalized with the flu.

Learn more about the FLU-IGIV trial here by calling the Clinical Trials Office at 484-628-8585.

Lyme

SLICE

Sex-based differences in the immunobiology and natural history of acute and convalescent Lyme disease (JHIRB00071455)

Johns Hopkins Primary Investigator: John Aucott, MD

Investigator: Debra Powell, MD

The purpose of this study is to examine sex-based differences in immune response and clinical outcomes in participants with Lyme disease.

Learn more about the SLICE trial by calling the Clinical Trials Office at 484-628-8585.

Nephrology

CKD & Anemia

ASCEND-NHQ

Anemia Studies in CKD: Erythropoiesis via a Novel PHI Daprodustat in Non-Dialysis participants evaluating Hemoglobin and Quality of life

Investigator: Trudy Demko, MD

This study is designed to evaluate safety, efficacy and quality of life of daprodustat compared to placebo in non-dialysis subjects with anemia associated with chronic kidney disease.

Learn more about the ASCEND-NHQ trial or call the Clinical Trials Office at 484-628-8585.

ASCEND-ND: Anemia Studies in CKD: Erythropoiesis
via a Novel PHI Daprodustat-Non-Dialysis

Investigator: Trudy Demko, MD

This study is designed to compare the cardiovascular safety of daprodustat (study med) to darbepoetin alfa and the efficacy of these medications for maintaining hemoglobin levels.

Learn more about the ASCEND-ND trial or call the Clinical Trials Office at 484-628-8585.

Neurology

Stroke

ARAMIS

Management of Acute Stroke Patients on Treatment with New Oral Anticoagulants: Addressing Real-world Anticoagulant Management Issues in Stroke Registry

Investigator: Karen Hoerst, MD

This study is designed to provide important and timely insight into the management of acute stroke patients who are on new oral anticoagulants.

Learn more about the ARAMIS trial or call the Clinical Trials Office at 484-628-8585.

Oncology

Lung Cancer Screening

A Study to Evaluate a Panel of Blood Biomarkers for Use in Patients Undergoing Evaluation for Lung Cancer

Investigator: Uday Dasika, MD

The purpose of this study is to develop a blood-based gene expression signature to be used in the detection of lung cancer in patients who underwent radiologic screening for lung cancer and had lung nodules detected.

Learn more about the Lung Cancer Biomarker by calling the Clinical Trials Office at 484-628-8585.

Weight Loss

Obesity

STEP 1

Research Study Investigating How Well Semaglutide Works in People Suffering From Overweight or Obesity

Investigator: Stephen Fehnel, MD

This study will look at the change in participants' body weight from the start to the end of the study. The weight loss in participants taking semaglutide (a new medicine) will be compared to the weight loss of participants taking "dummy" medicine. In addition to taking the medicine, participants will have talks with study staff about healthy food choices, how to be more physically active and what you can do to lose weight. Enrollment for this trial is closed.

Learn more about the STEP 1 trial here or call the Clinical Trials Office at 484-628-8585.

Women's Health

Sterilization

POET

Study to Assess Outcomes in Women Undergoing Either Hysteroscopic Sterilization (Essure®) or Laparoscopic Tubal Sterilization

Investigator: Stephen Fehnel, MD

This study is designed to assess post-procedural outcomes for women who chose to undergo either hysteroscopic sterilization (Essure®) or laparoscopic tubal sterilization.

Learn more about the POET trial here or call the Clinical Trials Office at 484-628-8585.